Resistance/susceptibility to lethal Sendai virus infection genetically linked to a mucociliary transport polymorphism

Resistance/susceptibility to lethal Sendai virus infection genetically linked to a mucociliary transport polymorphism.

Linkage was tested between a mucociliary transport polymorphism and resistance/susceptibility to lethal Sendai virus infection in segregant hybrid mice of C57BL/6J and DBA/2J parents. The distribution of paired phenotypes for tracheal mucociliary transport rates and susceptibility to lethal Sendai virus infection in 171 F1 X DBA/2J mice showed strong interaction of the parental phenotypes.

Enzyme - Linked Immunosorbent Assay to Detect the Sendai Virus Infection in Mice

COVID-19 infection leading to lethal spondylodiscitis with spinal abscess

Background: Secondary complications after SARS-CoV-2 virus infection including cardiovascular and neurological pose additional morbidity and mortality. Till date there no single case report of spondylodiscitis with spinal abscess after CVOID-19 infection. Case Description: A 71- year-old man presented with tachypnea and cough since 24 hours. He was febrile and the CT-chest showed typical pictu...

Multigenic control of resistance to Sendai virus infection in mice.

Experimental infection of mice with Sendai virus (SeV) is frequently used as a model of viral pathogenesis of human respiratory disease. To understand the differences in host response to SeV among mice strains, we carried out genetic mapping studies in DBA/2 (D2) (susceptible) and C57BL/6 (B6) (resistant) mice. F(1), F(2), and N(2) backcrossed mice were generated and examined for their disease ...

Genetics of natural resistance to Sendai virus infection in mice.

The genetics of resistance to a naturally occurring respiratory infection caused by Sendai virus was examined in F1, F2, and backcross progeny of resistant C57BL/6J and susceptible DBA/2J mice and in 25 recombinant inbred strains. An intranasal inoculum of 0.1 50% tissue culture infective dose (low dose) of Sendai virus caused 0% mortality in C57BL/6J and F1 mice and 73% mortality in DBA/2J mic...